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Histone methyltransferase EZH2 (PRC2 catalytic subunit) influences mitochondrial biology largely via transcriptional repression and chromatin remodeling: EZH2-mediated H3K27me3 can silence nuclear genes encoding mitochondrial regulators (including factors that modulate lipid metabolism, mitochondrial dynamics, or antioxidant responses), thereby reprogramming cellular metabolism toward or away from oxidative phosphorylation (285)

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3b), dodecanoyl-carnitine (Fig